G. Urabe

Partnership between epigenetic reader BRD4 and transcription factor CEBPD

This study identifies a partnership between BRD4 and CEBPD that promotes inflammatory SMC state transition and CEBPD transcription in vascular disease.

Angioplasty-induced epigenomic remodeling entails BRD4 and EZH2 hierarchical regulations

This study investigates how angioplasty induces epigenomic changes in rats, revealing BRD4 and EZH2's roles in regulating neointimal hyperplasia through histone modifications.

2MV/cm Pulsed Electric Fields Promote Transthyretin Amyloid Disintegration

The paper shows that 2 MV/cm pulsed electric fields disintegrate transthyretin amyloid without significant thermal or chemical changes.

Liposomes Under Real Cell Conditions Behave Like Real Cells with a Single Pulsed Electric Field

The paper shows that liposomes under high-conductivity conditions behave like cells by dividing when exposed to a single pulsed electric field.

The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation

This study identifies the BD2 domain of BRD4 as critical for EndoMT and vein graft neointima formation, suggesting it as a therapeutic target.

Silencing epigenetic writer DOT1L attenuates intimal hyperplasia

This study shows that inhibiting DOT1L reduces intimal hyperplasia in rat carotid arteries by lowering H3K79 methylation levels.

A non-canonical role and regulations of polo-like kinase-4 in fibroblast cell-type transition

This study identifies a non-canonical role for PLK4 in fibroblast cell-type transition and shows its regulation by BRD4 and PDGFR pathways, suggesting PLK4 inhibition as a potential anti-fibrotic intervention.

PERK inhibition mitigates restenosis and thrombosis - a potential low-thrombogenic anti-restenotic paradigm

This study shows that PERK inhibition reduces restenosis and thrombosis in animal models, suggesting it as a potential therapeutic strategy for drug-eluting stents.

Intense Pulsed Electric Fields Denature Urease Protein

This study shows that intense nsPEFs denature urease protein by altering its structure and enzyme activity, while having no effect on lysozyme or albumin.