Cancer BiologybioRxiv
Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker
T. A. Martins, N. Tatari, D. Kaymak…·G. Hutter
This paper develops a CAR T cell therapy that secretes a CD47 blocker to enhance anti-EGFRvIII efficacy against glioblastoma by modulating the tumor microenvironment.
DOI 10.1038/s41467-024-54129-w