In vivo genome-wide CRISPR screens identify SOCS1 as a major intrinsic checkpoint of CD4+ Th1 cell response
A. Sutra Del Galy, S. Menegatti, J. Fuentealba, F. Lucibello, J. Helft, A. Darbois, M. Saitakis, J. Tosello, D. Rookhuizen, L. Perrin, M. Deloger, P. Gestraud, G. Socie, S. Amigorena, O. Lantz, L. Menger
The paper identifies SOCS1 as a key intrinsic checkpoint limiting CD4+ Th1 cell response through in vivo CRISPR screens and shows targeting SOCS1 enhances antitumor T-cell therapy.
bioRxiv · Apr 12, 2021Immunology