Author

S. Amigorena

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Alloatti· 2 shared C. Goudot· 2 shared O. Lantz· 2 shared A. Beugnet· 1 shared A. Bonaud· 1 shared A. Darbois· 1 shared A. Peden· 1 shared A. Schneider· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersImmunology

A. Alloatti

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6 papers

Recent·Most cited

Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

A. Bonaud, L. Gargowitsch, S. Gilbert, E. Rajan, P. Canales-Herrerias, D. Stockholm, N. Rahman, M. Collins, D. L. Hill, A. Alloatti, N. Alouche, S. Balor, V. Soldan, D. Gillet, J. Barbier, , M. Espeli

This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.

bioRxiv · Jan 14, 2022 · PreprintImmunology

Induction of transposable element expression is central to innate sensing

D. C. Rookhuizen, P.-E. Bonte, M. Ye, T. Hoyler, M. Gentili, N. Burgdorf, S. Durand, F. Apprahamian, G. Kroemer, N. Manel, J. Waterfall, R. Milne, C. Goudot, G. J. Towers, S. Amigorena

The paper shows that exogenous PAMPs epigenetically activate LINE1 TEs, which engage cGAS to enhance innate immune responses.

bioRxiv · Sep 10, 2021 · PreprintImmunology

In vivo genome-wide CRISPR screens identify SOCS1 as a major intrinsic checkpoint of CD4+ Th1 cell response

A. Sutra Del Galy, S. Menegatti, J. Fuentealba, F. Lucibello, J. Helft, A. Darbois, M. Saitakis, J. Tosello, D. Rookhuizen, L. Perrin, M. Deloger, P. Gestraud, G. Socie, S. Amigorena, O. Lantz, L. Menger

The paper identifies SOCS1 as a key intrinsic checkpoint limiting CD4+ Th1 cell response through in vivo CRISPR screens and shows targeting SOCS1 enhances antitumor T-cell therapy.

bioRxiv · Apr 12, 2021Immunology

Contribution of resident and circulating precursors to tumor-infiltrating CD8+ T cell populations in non-small cell lung cancer patients

C. Metoikidou, P. Gueguen, T. Dupic, M. Lawand, C. Goudot, S. Baulande, S. Lameiras, O. Lantz, N. Girard, A. Seguin-Givelet, M. Lefevre, T. Mora, A. Walczak, J. J. Waterfall, S. Amigorena

The paper identifies two CD8+ TIL subpopulations in NSCLC, one circulating and one resident, which transition into terminally differentiated cells through a unique state.

bioRxiv · Aug 14, 2020Immunology

Small molecule enhancers of endosome-to-cytosol import augment anti-tumour immunity

P. Kozik, M. Gros, D. N. Itzhak, L. Joannas, J. G. Magalhaes, A. Alloatti, E. Del Nery, G. H. Borner, S. Amigorena

The paper identifies small molecule enhancers of endosome-to-cytosol antigen import that improve cross-presentation and anti-tumour immunity.

bioRxiv · May 5, 2020Immunology

Surface LSP1 is a phenotypic marker distinguishing human classical versus monocyte-derived dendritic cells

S. Moutel, A. Beugnet, A. Schneider, B. Lombard, D. Loew, S. Amigorena, F. Perez, E. Segura

bioRxiv · Oct 24, 2019Immunology