Author

J. Helft

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C.-A. Dutertre· 2 shared F. Ginhoux· 2 shared P. Guermonprez· 2 shared Y. Missolo-Koussou· 2 shared A. Darbois· 1 shared A. Nicolas· 1 shared A. Saxena· 1 shared A. Sutra Del Galy· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

C.-A. Dutertre

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

In vivo genome-wide CRISPR screens identify SOCS1 as a major intrinsic checkpoint of CD4+ Th1 cell response

A. Sutra Del Galy, S. Menegatti, J. Fuentealba, F. Lucibello, J. Helft, A. Darbois, M. Saitakis, J. Tosello, D. Rookhuizen, L. Perrin, M. Deloger, P. Gestraud, G. Socie, S. Amigorena, O. Lantz, L. Menger

The paper identifies SOCS1 as a key intrinsic checkpoint limiting CD4+ Th1 cell response through in vivo CRISPR screens and shows targeting SOCS1 enhances antitumor T-cell therapy.

bioRxiv · Apr 12, 2021Immunology

Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients.

R. N. Ramos, Y. Missolo-Koussou, Y. Gerber-Ferder, C. Bromley, M. Bugatti, N. G. Nunez, J. Boari Tosello, W. Richer, J. Denizeau, C. Sedlik, P. Caudana, F. Kotsias, L. L. Niborski, S. Viel, M. Bohec, , J. Helft

The paper identifies FOLR2+ macrophages in breast cancer that correlate with improved patient survival and co-localize with CD8+ T cells across multiple cancers.

bioRxiv · Apr 12, 2021 · PreprintImmunology

Engineered niches support the development of human dendritic cells in humanized mice

G. Anselmi, K. Vaivode, C.-A. Dutertre, P. Bourdely, Y. Missolo-Koussou, E. Newell, O. Hickman, K. Wood, A. Saxena, J. Helft, F. Ginhoux, P. Guermonprez

This study shows engineered mesenchymal stromal cells can generate human dendritic cells in vivo, closely resembling blood-derived cDCs.

bioRxiv · Nov 8, 2019Immunology