S. Menegatti

The paper develops peptide-based adsorbents to purify AAV2 from HEK 293 cell lysates, achieving high recovery and reduced host proteins with comparable transduction activity to commercial methods.

The paper designs 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells using a combination of computational and experimental methods.

The paper identifies SOCS1 as a key intrinsic checkpoint limiting CD4+ Th1 cell response through in vivo CRISPR screens and shows targeting SOCS1 enhances antitumor T-cell therapy.

This paper uses magnetized yeast displaying protein targets to screen mRNA display peptide libraries and identifies ligands with measured binding affinities.

This paper introduces a quantitative yeast-yeast two hybrid system to discover and estimate binding affinities of protein-protein interactions.

The paper develops methods to cyclize peptides using transglutaminase in yeast display libraries and identifies cyclic peptides that bind YAP and its WW domains with high selectivity.

This paper identifies membrane-permeating cyclic peptides (MPPs) capable of crossing both cytoplasmic and outer embryonic membranes, outperforming linear counterparts in permeation.

The paper demonstrates a method to isolate membrane protein binders using magnetized yeast cell targets, achieving efficient enrichment of low-frequency binders in a single screening round.