Cancer BiologybioRxivPreprint
The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance
P. Rai, L. Zhang, C. I. Troccoli…·A. Beuve
This study identifies the soluble guanylyl cyclase (sGC) pathway as a target for castration-resistant prostate cancer (CRPC) treatment, showing that riociguat inhibits CRPC growth and enhances radiation response.
DOI 10.1101/2023.05.03.537252