Author

D. Kwon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Immunology· 2 Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 6 Research Focus:cell type annotation· 4 Organism:mouse· 3 Assay:proteomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

M. A. Correia· 2 shared Y. Liu· 2 shared A. Beuve· 1 shared A. Bianchi· 1 shared A. C. Lockhart· 1 shared A. H. Sims· 1 shared A. Hutchinson· 1 shared A. L. Burlingame· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

M. A. Correia

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance

P. Rai, L. Zhang, C. I. Troccoli, B. Mateo-Victoriano, L. Misiara, E. N. Jackson, P. Shu, T. M. Plastini, W. Tao, D. Kwon, X. Chen, J. Sharma, M. Jorda, J. L. Gulley, M. Bilusic, , A. Beuve

This study identifies the soluble guanylyl cyclase (sGC) pathway as a target for castration-resistant prostate cancer (CRPC) treatment, showing that riociguat inhibits CRPC growth and enhances radiation response.

bioRxiv · May 3, 2023 · PreprintCancer Biology

Neutrophil-Mediated Stromal-Tumor IL-6/STAT-3 Signaling Underlies the Association between Neutrophil-to-Lymphocyte Ratio Dynamics and Chemotherapy Response in Localized Pancreatic Cancer: A Hybrid Clinical-Preclinical Study

I. de Castro Silva, P. Sharma, A. Bianchi, N. Deshpande, S. Mehra, J. England, P. J. Hosein, D. Kwon, N. Merchant, J. Datta

This study shows that neutrophil-to-lymphocyte ratio (NLR) dynamics predict chemotherapy response in pancreatic cancer and that targeting NLR improves chemosensitivity by modulating IL-6/STAT-3 signaling.

bioRxiv · May 4, 2022 · PreprintImmunology

Social mobility and biological aging among older adults in the United States

G. H.-J. Graf, Y. Zhang, B. W. Domingue, K. M. Harris, M. Kothari, D. Kwon, P. A. Muennig, D. W. Belsky

This study examines how social mobility affects biological aging in older U.S. adults, finding that upward mobility is linked to slower aging but with racial disparities in educational mobility benefits.

bioRxiv · Oct 19, 2021Physiology

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation

B. J. Fraser, S. Beldar, A. Seitova, A. Hutchinson, D. Mannar, Y. Li, D. Kwon, R. Tan, R. P. Wilson, K. Leopold, S. Subramaniam, L. Halabelian, C. H. Arrowsmith, F. Benard

This study characterizes the structure and function of TMPRSS2, a protease involved in SARS-CoV-2 activation, and identifies features for developing selective inhibitors.

bioRxiv · Jun 23, 2021Biochemistry

LBH is a cancer stem cell- and metastasis-driving oncogene essential for WNT stem cell function in breast cancer

K. Garikapati, K. Ashad-Bishop, S. Hong, R. Qureshi, M. E. Rieger, L. E. Lindley, B. Wang, D. J. Azzam, M. Khanlari, M. Nadji, C. Jain, D. Kwon, Y. Ban, Z. Gao, S. X. Chen, , K. J. Briegel

This study identifies LBH as a key oncogene driving cancer stem cell function and metastasis in breast cancer through WNT pathway activation.

bioRxiv · Jan 29, 2021 · PreprintCancer Biology

Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/ Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance.

D. Kwon, S.-m. Kim, P. Jacob, Y. Liu, M. A. Correia

This study shows that genetic ablation of gp78/AMFR in mice stabilizes hepatic P450 enzymes, enhancing their drug metabolism and potentially affecting drug response and toxicity.

Molecular Pharmacology · Nov 1, 2019Peer-reviewedPharmacology & Toxicology

Contrasting inflammatory signatures in peripheral blood and bronchoalveolar cells reveal compartment-specific effects of HIV infection.

D. Muema, M. Mthembu, A. Schiff, U. Singh, C. Bjorn, T. Bassett, S. S. Rasehlo, K. Nyamande, D. F. Khan, P. Maharaj, M. Mitha, M. Suleman, Z. Mhlane, T. Naidoo, D. Ramjit, , E. B. Wong

This study compares HIV-induced gene expression in peripheral blood and bronchoalveolar cells, revealing distinct inflammatory signatures and compartment-specific effects.

bioRxiv · Oct 23, 2019Immunology

A NOVEL MECHANISM FOR NF-κB-ACTIVATION VIA IκB-AGGREGATION: IMPLICATIONS FOR HEPATIC MALLORY-DENK-BODY INDUCED INFLAMMATION

Y. Liu, M. J. Trnka, S. Guan, D. Kwon, D.-H. Kim, J.-J. Chen, P. A. Greer, A. L. Burlingame, M. A. Correia

This study identifies a novel mechanism of NF-κB activation through IκB sequestration into insoluble aggregates along with aggregation-prone proteins in MDB-inducing models.

bioRxiv · Mar 21, 2019Cell Biology

Measurements of three-dimensional refractive index tomography and membrane deformability of live erythrocytes from Pelophylax nigromaculatus

G. Kim, M. Lee, S. Youn, E. Lee, D. Kwon, J. Shin, S. Lee, Y. S. Lee, Y. Park

This study measures 3D refractive index and membrane properties of live erythrocytes from Pelophylax nigromaculatus to compare interspecific differences with mammals.

bioRxiv · Oct 20, 2017Biophysics