Author

L. Morales-Nebreda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. D. Singer· 3 shared H. Abdala-Valencia· 3 shared Y. Politanska· 3 shared K. A. Helmin· 2 shared M. A. Torres Acosta· 2 shared N. S. Markov· 2 shared A. Bharat· 1 shared A. C. Argento· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

B. D. Singer

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3 papers

Recent·Most cited

ImmunologyNaturePeer-reviewedJan 11, 2021

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

R. A. Grant, L. Morales-Nebreda, N. S. Markov…·The NU SCRIPT Study Investigators

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

DOI 10.1038/s41586-020-03148-w

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivJun 5, 2020

Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

L. Morales-Nebreda, K. A. Helmin, N. S. Markov…·B. D. Singer

This study shows that aging impairs Treg cell function during recovery from influenza pneumonia, with transcriptional and DNA methylation changes contributing to reduced reparative capacity in aged mice.

DOI 10.1172/jci.insight.141690

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivFeb 3, 2020

Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

K. A. Helmin, L. Morales-Nebreda, M. A. Torres Acosta…·B. D. Singer

This study shows that maintenance DNA methylation, regulated by Uhrf1, is essential for Treg cell development and stability of their suppressive function.

DOI 10.1172/jci137712

mouseDNA methylation

𝕏 PostBluesky