Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
M. A. Torres Acosta, N. Mambetsariev, C. P. R. Flores, K. A. Helmin, Q. Liu, A. M. Joudi, L. Morales-Nebreda, J. Gurkan, K. Cheng, H. Abdala-Valencia, S. E. Weinberg, B. D. Singer
This study shows AMPK is necessary for Treg cell adaptation to metabolic stress in tumors and lung injury but not for baseline immune homeostasis.
bioRxiv · Nov 29, 2023 · PreprintImmunology
N. S. Michki, B. D. Singer, J. V. Perez, A. J. Thomas, V. Natale, K. A. Helmin, J. Wright, L. Cheng, L. R. Young, H. M. Lederman, S. A. McGrath-Morrow
This study uses bulk RNA-seq to identify inflammatory phenotypes in ataxia telangiectasia by analyzing peripheral blood mononuclear cells.
bioRxiv · Oct 5, 2023Immunology
R. A. Grant, T. A. Poor, L. Sichizya, E. Diaz, J. I. Bailey, S. Soni, K. J. Senkow, X. G. Perez-Leonor, H. Abdala-Valencia, Z. Lu, H. K. Donnelly, R. M. Tighe, J. W. Lomasney, R. G. Wunderink, B. D. Singer, , The NU SCRIPT Investigators
The paper shows that prolonged exposure to lung-derived cytokines in COVID-19 patients activates microglia, and corticosteroids reduce this inflammatory response.
bioRxiv · Jul 28, 2023Immunology
L. Hassler, J. Wysocki, J. T. Ahrendsen, M. Ye, I. Gelarden, V. Nicolaescu, A. Tomatsidou, H. Gula, C. Cianfarini, N. Khurram, Y. Kanwar, B. D. Singer, G. Randall, D. M. Missiakas, J. Henkin, D. Batlle
This study compares intranasal and systemic administration of bioengineered soluble ACE2 in mice, finding intranasal delivery provides better survival and brain protection against SARS-CoV-2.
bioRxiv · Dec 5, 2022 · PreprintPathology
N. S. Michki, R. Ndeh, K. A. Helmin, B. D. Singer, S. A. McGrath-Morrow
The paper shows that DNA methyltransferase inhibition in neonatal mice with E. coli pneumonia reduces methylation of interferon-responsive genes, shifting gene expression toward a juvenile-like profile.
bioRxiv · Sep 30, 2022 · PreprintImmunology
S. A. McGrath-Morrow, J. Venezia, R. Ndeh, B. D. Singer, R. Cimbro, M. Soloski, A. L. Scott
This study compares immune responses in neonatal and juvenile mice to E. coli pneumonia, identifying age-related differences in cellular dynamics and gene expression that may explain increased neonatal susceptibility.
bioRxiv · Sep 21, 2022Immunology
R. A. Grant, L. Morales-Nebreda, N. S. Markov, S. Swaminathan, E. R. Guzman, D. A. Abbott, H. K. Donnelly, A. Donayre, I. A. Goldberg, Z. M. Klug, N. Borkowski, Z. Lu, H. Kihshen, Y. Politanska, L. Sichizya, , The NU SCRIPT Study Investigators
The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.
Nature · Jan 11, 2021Peer-reviewedImmunology
L. Morales-Nebreda, K. A. Helmin, N. S. Markov, R. Piseaux, M. A. Torres Acosta, H. Abdala-Valencia, Y. Politanska, B. D. Singer
This study shows that aging impairs Treg cell function during recovery from influenza pneumonia, with transcriptional and DNA methylation changes contributing to reduced reparative capacity in aged mice.
bioRxiv · Jun 5, 2020Immunology
K. A. Helmin, L. Morales-Nebreda, M. A. Torres Acosta, K. R. Anekalla, S.-Y. Chen, H. Abdala-Valencia, Y. Politanska, P. Cheresh, M. Akbarpour, E. M. Steinert, S. E. Weinberg, B. D. Singer
This study shows that maintenance DNA methylation, regulated by Uhrf1, is essential for Treg cell development and stability of their suppressive function.
bioRxiv · Feb 3, 2020Immunology
A. C. McQuattie-Pimentel, Z. Ren, N. Joshi, S. Watanabe, T. Stoeger, M. Chi, Z. Lu, L. Sichizya, R. Piseaux, C.-I. Chen, S. Soberanes, P. A. Reyfman, J. M. Walter, K. R. Anekalla, J. M. Davis, , G. S. Budinger
This study shows that the aging lung microenvironment shapes alveolar macrophage identity, influencing their phenotype during aging and after injury.
bioRxiv · Jul 29, 2019 · PreprintImmunology