Cancer BiologybioRxiv
Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy
E. Dodagatta-Marri, H.-Y. Ma, B. Liang…·D. Sheppard
This study shows that blocking integrin αvβ8 on T cells enhances anti-tumor immunity in multiple syngeneic models and is effective even when tumor cells do not express the integrin.
DOI 10.1016/j.celrep.2021.109309