Author

L. Rolas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

S. Nourshargh· 2 shared A. Barkaway· 1 shared A. Gil-Ordonez· 1 shared A. Komatsubara· 1 shared B. Marcos-Ramiro· 1 shared C.-G. Pack· 1 shared F. J. Ortega-Nogales· 1 shared H. Kimura· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

S. Nourshargh

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2 papers

Recent·Most cited

Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome

Y. Kono, C.-G. Pack, T. Ichikawa, A. Komatsubara, S. A. Adam, K. Miyazawa, L. Rolas, S. Nourshargh, O. Medalia, R. D. Goldman, T. Fukuma, H. Kimura, T. Shimi

This study investigates the delayed localization of A-type lamins to nuclear envelope rupture sites in HGPS, identifying farnesylation and proteolytic cleavage as key factors affecting this process.

bioRxiv · Sep 2, 2023Cell Biology

Isoprenylcysteine carboxylmethyltransferase basedtherapy for Hutchinson Gilford progeria syndrome

B. Marcos-Ramiro, A. Gil-Ordonez, N. I. Marin-Ramos, F. J. Ortega-Nogales, M. Balabasquer, P. Gonzalo, L. Rolas, A. Barkaway, S. Nourshargh, V. Andres, M. Martin-Fontecha, M. L. Lopez-Rodriguez, S. Ortega-Gutierrez

This study develops UCM-13207, an ICMT inhibitor that reduces progerin nuclear accumulation and improves phenotypes in progeria models.

bioRxiv · Jul 23, 2020Pharmacology & Toxicology