Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome
Y. Kono, C.-G. Pack, T. Ichikawa, A. Komatsubara, S. A. Adam, K. Miyazawa, L. Rolas, S. Nourshargh, O. Medalia, R. D. Goldman, T. Fukuma, H. Kimura, T. Shimi
This study investigates the delayed localization of A-type lamins to nuclear envelope rupture sites in HGPS, identifying farnesylation and proteolytic cleavage as key factors affecting this process.
bioRxiv · Sep 2, 2023Cell Biology