Cancer BiologybioRxivPreprint
Vitamin D promotes DNase1L3 to degrade ecDNA and inhibit the malignant progression of hepatocellular carcinoma
H. Zhang, L.-n. Qin, Q.-q. Li…·T. Sun
This study shows vitamin D reduces ecDNA in hepatocellular carcinoma by stabilizing DNase1L3 via its transporter GC, leading to tumor suppression.
DOI 10.1101/2023.08.30.555532