Author

Lan Huang

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Organism:human· 1

Frequent Co-Authors

Clinton YuiD· 3 shared Michael R. HoopmanniD· 2 shared Robert L. MoritziD· 2 shared Rosa VineriD· 2 shared Abhilash BarpandaiD· 1 shared Akul Naik· 1 shared Albert J. R. HeckiD· 1 shared Alex ZelteriD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

Clinton YuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Extending structural surfaceomics to identify aberrant conformations of tumor surface proteins as potential immunotherapy targets

Audrey Kishishita, Sabine Cismoski, Tianna Grant, Rucha Deo, Sanjana Prudhvi, Catherine Sue, Abhilash Barpanda, Clinton Yu, Sanjyot Vinayak Shenoy, Sarah Berman, Audrey G. Reeves, Haolong Li, Tianyi Liu, Akul Naik, Deeptarup Biswas, , Arun P. Wiita

This paper expands structural surfaceomics to identify cancer-specific protein conformations across multiple tumor models, revealing potential immunotherapy targets through crosslinking mass spectrometry and structural modeling.

bioRxiv · May 18, 2026 · PreprintCancer Biology

LENG8 mediates RNA nuclear retention and degradation in eukaryotes

Lusong Tian, Liang Liu (50022), Yoseop Yoon, Lindsey V. Soles, Marielle Cárdenas Valdez, Joshua Jeong, Clinton Yu, Lan Huang, Yongsheng Shi

This study identifies LENG8 as a conserved RNA nuclear retention factor that prevents misprocessed mRNAs and noncoding RNAs from being exported, ensuring proper nuclear quality control.

Molecular Cell · Mar 19, 2026Peer-reviewedMolecular Biology

Pentatricopeptide repeat poly(A) binding protein from mitochondria of trypanosomes

Mikhail V. Mesitov, Tian Yu, Takuma Suematsu, Francois M. Sement, Liye Zhang, Clinton Yu, Lan Huang, Inna Aphasizheva

The paper identifies KPAF4, a mitochondrial PABP in Trypanosoma brucei, which regulates mRNA editing and 3' modification by preventing premature A/U-tailing and ensuring transcript stability.

bioRxiv · Oct 29, 2018 · PreprintBiochemistry

Cross-linking/Mass Spectrometry: A Community-Wide, Comparative Study Towards Establishing Best Practice Guidelines

Claudio Iacobucci, Christine Piotrowski, Ruedi Aebersold, Bruno C. Amaral, Philip Andrews, Christoph Borchers, Nicolas I. Brodie, James E. Bruce, Stéphane Chaignepain, Juan D. Chavez, Stéphane Claverol, Jürgen Cox, Gianluca Degliesposti, Meng-Qiu Dong, Nufar Edinger, , Andrea Sinz

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.

bioRxiv · Sep 26, 2018 · PreprintBiochemistry