Clinton Yu

This paper introduces xGL-APMS to profile endogenous galectin-3 interactions at the cell surface, identifying 125 interactors on Jurkat cells and 69 on mouse thymocytes.

The paper evaluates DSSO crosslinking strategies using Protein Prospector and Touchstone, finding that DSSO's advantage comes from backbone fragmentation, not diagnostic ions, and that MS3 is better for proteome-scale samples.

This study shows cyclin B3-CDK1/2 drives mitotic progression and fidelity in cancer cells, with overexpression accelerating mitosis and depletion disrupting it in multiple cancer models.

This paper expands structural surfaceomics to identify cancer-specific protein conformations across multiple tumor models, revealing potential immunotherapy targets through crosslinking mass spectrometry and structural modeling.

This study identifies LENG8 as a conserved RNA nuclear retention factor that prevents misprocessed mRNAs and noncoding RNAs from being exported, ensuring proper nuclear quality control.

This paper shows that an orthosteric inhibitor of the COP9 signalosome achieves high potency through a molecular glue mechanism that enhances substrate-dependent binding.

This paper introduces a novel trioxane-based cross-linker, TSTO, for XL-MS that enables fast and unambiguous identification of multimeric protein interactions, revealing new structural details of protein complexes.

The paper identifies NEMF-mediated CAT-tailing as a mechanism that directs substrates through distinct degradation pathways during translocation-associated quality control.

This study identifies PHD2 interaction hotspots and reveals its role in regulating protein neddylation through interaction with the COP9 Signalosome complex.

PL-ExM combines proximity labeling and expansion microscopy to visualize 3D interactome structures and assess PL technique performance.

This study discovers that native MCC from Leishmania tarentolae forms filaments, determines its structure, and proposes a new model for its catalytic mechanism.

The paper identifies KPAF4, a mitochondrial PABP in Trypanosoma brucei, which regulates mRNA editing and 3' modification by preventing premature A/U-tailing and ensuring transcript stability.