Robert L. Moritz

The paper identifies protein interactors of COPD GWAS genes using AP-MS and network analysis, revealing a disease network module involving 8 proteins.

This paper expands structural surfaceomics to identify cancer-specific protein conformations across multiple tumor models, revealing potential immunotherapy targets through crosslinking mass spectrometry and structural modeling.

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

This study identifies UBR-1 as a hub regulating glutamate homeostasis through a signaling axis, affecting locomotion and developmental viability in C. elegans.

The paper expands and refines a reference catalog of human non-canonical open reading frames (ncORFs) by incorporating more datasets and introducing a translation signature score framework to prioritize high-quality ncORFs.

This study shows that glycosylation of PfTRAP's TSR domain is essential for sporozoite motility and invasion, as glyco-null mutants exhibit severe fitness defects.

The paper audits error control in twelve crosslinking mass spectrometry pipelines using ground-truth designs, finding some pipelines exceed false discovery rates by up to 29-fold.

The paper provides an updated Candida albicans PeptideAtlas proteomics resource with detailed PTM data and tools for analysis.

The paper assesses MS-based identifications of unannotated human microproteins, finding large variation in reported proteins and PSM quality across studies.

This study identifies the global release of translational repression in Plasmodium parasites during host-to-vector transmission using transcriptomics and proteomics.

This study confirms that the circumsporozoite protein (CSP) of Plasmodium sporozoites is GPI-anchored using metabolic labeling and mass spectrometry.

This study integrates omics data to reveal post-transcriptional regulation mechanisms in Halobacterium salinarum NRC-1, showing 54% of genes are regulated by multiple mechanisms and 7% show conditional regulation.

The paper summarizes recent developments in the Crux toolkit for analyzing bottom-up proteomics data, including speedups, new features, and tools.

This paper outlines a community-driven initiative to create a consolidated catalog of human Ribo-seq ORFs, addressing the lack of standardized annotation for these features.

The paper examines organ-specific proteins in mice across different genetic backgrounds to assess their diversity and define robustness scores for quality assessment.

The paper identifies a non-responder phenotype in the murine gut microbiome that exhibits resistance to cefoperazone, showing upregulated antimicrobial resistance genes and reduced central metabolism during antibiotic treatment.

The paper identifies 10 blood proteins with altered serum levels in early Lyme disease patients, developing a 10-protein panel for potential diagnostic use.

The paper updates the HPP MS Data Interpretation Guidelines to improve accuracy and address new workflows and data standards.

PTMProphet provides localization confidence for post-translational modifications in proteomics data, improving accuracy for downstream analysis.

This study characterizes the transcriptome and histone epigenome of Plasmodium vivax sporozoites, revealing transcriptional and post-transcriptional control mechanisms and potential pathways for hypnozoite formation.

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.

The paper presents the complete genome sequence of Borrelia burgdorferi MM1 strain, identifies it as a new sequence type, and provides the first contiguous assembly of a specific plasmid.