Gustavo W. Leone

This study shows that inhibiting EZH2 alters 3D chromatin structure in SCLC, reactivating MHC genes and enhancing immunogenicity.

This study shows that primary hepatocytes can replicate DNA without ORC2, similar to cancer cell lines, by loading MCM2-7 complexes.

The paper shows that parietal trophoblast giant cells regulate hematopoietic stem cell development in the placenta through paracrine signaling.

This study shows that inhibiting β-catenin/CBP interaction with ICG-001 alters 3D chromatin structure in pancreatic cancer, affecting insulin signaling and promoting tumor growth.

The paper develops a deep learning approach to estimate cell cycle protein expression from 2D fluorescent images by segmenting nuclei and quantifying fluorescent labels.