Peng Li

AMD1-driven MTA production sustains chemoresistance by rewiring PMN-MDSC immunosuppression

This study identifies AMD1-driven MTA production as a mechanism sustaining chemoresistance by enhancing PMN-MDSC immunosuppression.

Evaluation of gaseous ozone technology for decontaminating porcine reproductive and respiratory syndrome virus (PRRSV) and porcine epidemic diarrhea virus (PEDV) from non-porous surface in truck cabins

This study evaluates gaseous ozone's effectiveness in decontaminating PRRSV and PEDV from truck cabin surfaces, finding inconsistent and limited viral titer reduction.

Single-cell profiling reveals MMP7-associated epithelial transition and immune-stromal remodeling in esophageal carcinogenesis

This study uses single-cell transcriptomics to identify MMP7-associated epithelial transitions and immune-stromal changes in esophageal carcinogenesis.

Structural Characterization of Calcium-Dependent Calmodulin-Calmidazolium Binding using Capillary Vibrating Sharp-Edge Spray-based Native Mass Spectrometry and In-Droplet Hydrogen Deuterium Exchange Mass Spectrometry

This study uses native mass spectrometry and hydrogen deuterium exchange to analyze calcium-dependent calmodulin-calmidazolium interactions, revealing ligand-induced conformational changes and binding affinity.

Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

This paper develops a spermatocytes-tropic mRNA-LNP delivery system to treat genetic spermatogenic disorders, showing restoration of spermatogenesis in mouse models.

A dominant CIDEC variant segregates with familial obesity by increasing lipid droplet size in adipocytes

This study identifies a dominant CIDEC variant causing familial obesity by increasing lipid droplet size in adipocytes through structural and functional changes.

Intradental mechano-nociceptors serve as sentinels that prevent tooth damage

This study identifies intradental high-threshold mechano-nociceptors that detect tooth damage, produce pain, and trigger protective reflexes.

Suaeda Salsa Hyperspectral Index (SSHI) for mapping S. salsa in coastal wetlands using hyperspectral satellite imagery

This paper introduces a hyperspectral index (SSHI) for mapping Suaeda Salsa using satellite imagery, achieving high accuracy in coastal wetland monitoring.

PD-1 negatively regulates helper T cell differentiation into Th2

This study shows PD-1 inhibits Th2 cell differentiation and allergic inflammation in mice, suggesting its therapeutic potential for Th2-driven diseases.

Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.