Cancer BiologybioRxivPreprint
Lineage recording reveals hijacked hepatic progenitor states as a common origin of HCC and ICC
Jinyong Fan, Jiazheng Pei, Nuo Xu…·Xin Liu
The paper uses CERAMIC to trace liver tumor initiation, identifying Hep_Bi-zonal cells as the origin of HCC and ICC and revealing peroxisomal metabolism and macrophage niches as key factors.