Lin Liu

The Par complex regulates apical-basal cell polarity through modulation of FAK signaling homeostasis

This study shows that the Par complex regulates cell polarity and differentiation by modulating FAK signaling through the AKT-FURIN-LEFTY pathway in mouse embryonic stem cells.

Scaling genome annotation across the eukaryotic tree of life with OrionGeno

OrionGeno annotates over 5,300 eukaryotic genomes using a phylogeny-aware deep learning model, outperforming existing methods in gene and protein structure prediction.

Long-read RNA-seq resolves isoform-level and context-specific regulatory architecture of complex traits in cattle

The paper uses long-read RNA-seq to uncover isoform-level and context-specific regulatory effects in cattle, improving the resolution of molecular atlases and GWAS loci.

An Asynchronous Production Line of Meiotic Prophase I in the Mouse Fetal Ovary

The paper challenges the notion of synchronous meiosis initiation in mouse fetal ovaries, showing asynchronous entry and progression from E12.5 to E16.5, supported by a predictive meiotic clock model.

Temporal coordination of collective migration and lumen formation by antagonism between two nuclear receptors

The paper shows that E75 and DHR3 nuclear receptors antagonize each other to regulate the temporal order and interval between collective migration and lumen formation in Drosophila border cells.

Dark selection for JAK/STAT-inhibitor resistance in chronic myelomonocytic leukemia

The paper challenges the classic U-shape model of resistance by proposing alternative population-level models for ruxolitinib resistance in CMML and explores the role of oxygen and cytokine signaling in resistance dynamics.

Measuring and modeling diffuse scattering in protein X-ray crystallography

This paper measures and models diffuse scattering in protein X-ray crystallography using cyclophilin A and trypsin crystals, showing that LLM and NM models better agree with diffuse data than TLS models.