Lin Liu

This study synthesizes oligosaccharides from Streptococcus pneumoniae serotypes 35B and 35D to investigate their binding to complement and serum factors, revealing the role of O-acetylation in immune evasion and vaccine efficacy.

This paper develops a stop-and-go chemoenzymatic method to synthesize asymmetrical bi-antennary glycans and uses them to study receptor binding evolution of human influenza A viruses.

This paper identifies 9-O-acetylated sialic acids as a ligand for the SARS-CoV-2 NTD, revealing a dual-receptor functionality in the S1 domain that was rapidly selected against.