Cell BiologybioRxivPreprint
A novel mouse allele of the DNA/RNA helicase senataxin (Setxspcar3) causing meiotic arrest of spermatocytes and male infertility
Y. Fujiwara, K. Saito, F. Sun…·M. A. Handel
This study identifies a new Setx allele causing male infertility and female subfertility in mice by disrupting meiosis and spermatogenesis through R-loop accumulation and DNA damage.
DOI 10.1101/2023.04.12.536672