Author

M. A. Seeliger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. D. Chodera· 3 shared B.-T. Berger· 2 shared S. K. Albanese· 2 shared S. Knapp· 2 shared A. Lyczek· 1 shared A. M. Rangwala· 1 shared C. Jeans· 1 shared D. L. Parton· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

J. D. Chodera

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivJan 13, 2023

Death by a Thousand Cuts -- Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology

I. R. Outhwaite, S. Singh, B.-T. Berger…·M. A. Seeliger

This paper presents a method to improve kinase inhibitor selectivity by combining inhibitors with divergent off-target activities, validated using a NanoBRET assay.

DOI 10.7554/elife.86189

proteomicsdeep learning

𝕏 PostBluesky

BiochemistrybioRxivJun 28, 2021

Mutation in Abl kinase with altered drug binding kinetics indicates a novel mechanism of imatinib resistance

A. Lyczek, B.-T. Berger, A. M. Rangwala…·M. A. Seeliger

The paper identifies a mutation in Abl kinase that causes imatinib resistance through altered drug dissociation kinetics rather than reduced binding affinity.

DOI 10.1073/pnas.2111451118

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivFeb 25, 2016

An open library of human kinase domain constructs for automated bacterial expression

S. K. Albanese, D. L. Parton, M. Isık…·J. D. Chodera

This paper presents a library of 52 human kinase domain constructs expressed in bacteria using phosphatase coexpression, enabling high-throughput biochemical and biophysical studies.

DOI 10.1021/acs.biochem.7b01081

humanproteomics

𝕏 PostBluesky