Author

M. Botto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. Lamers· 2 shared A. Borsellini· 1 shared A. Owen· 1 shared C. Giacomassi· 1 shared C. Johansson· 1 shared J. Strid· 1 shared K. J. Woollard· 1 shared S. Murthy· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

M. Lamers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung anti-viral immunity

W. D. Jackson, C. Giacomassi, S. Ward, A. Owen, T. Luis, S. Spear, K. J. Woollard, C. Johansson, J. Strid, M. Botto

This study shows that TLR7 activation at epithelial barriers triggers emergency myelopoiesis, leading to reduced lung viral load during RNA virus infection.

bioRxiv · Feb 6, 2023Immunology

A high-throughput exonuclease assay based on the fluorescent base analog 2-aminopurine

M. Botto, S. Murthy, M. Lamers

The paper introduces a high-throughput exonuclease assay using 2-aminopurine and identifies a novel inhibitor of Mycobacterium tuberculosis PHP-exonuclease.

bioRxiv · Sep 12, 2022 · PreprintBiochemistry

A four-point molecular handover during Okazaki maturation

M. Botto, A. Borsellini, M. Lamers

The paper reveals a four-point molecular handover mechanism during Okazaki fragment maturation in E. coli, showing how DNA polymerases, endonuclease, and ligase coordinate to remove RNA primers.

bioRxiv · Aug 2, 2022Biochemistry