Author

S. Spear

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Approach:statistical model· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3

Frequent Co-Authors

P. Spiliopoulou· 3 shared H. B. Mirza· 2 shared H. C. Keun· 2 shared I. Garner· 2 shared I. McNeish· 2 shared N. Iyer· 2 shared R. Brown· 2 shared Y. Xu· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

P. Spiliopoulou

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance

I. Dye, S. Laing, I. Garner, H. B. Mirza, N. Iyer, N. Brady, P. Spiliopoulou, S. Spear, J. Robinson, F. Fiorentino, M. J. Fuchter, D. J. Murphy, I. J. McNeish, R. Brown

This study shows that inhibiting H3K27/H3K9 methylation maintenance reverses cMYC-mediated immune repression in cancer, improving survival in mouse models.

bioRxiv · Oct 18, 2023 · PreprintCancer Biology

Heme oxygenase-1 expressing omental macrophages as a therapeutic target in ovarian high grade serous carcinoma

S. Spear, O. Le Saux, H. B. Mirza, K. Tyson, J. Bickel, F. Grundland Freile, A. P. Siskos, C. Balcells, J. B. Walton, C. Woodman, D. P. Ennis, N. Iyer, C. Aguirre Hernandez, Y. Xu, P. Spiliopoulou, , I. A. McNeish

This study identifies HMOX1-expressing omental macrophages as a therapeutic target and biomarker for poor prognosis ovarian high-grade serous carcinoma.

bioRxiv · Jul 18, 2023 · PreprintCancer Biology

TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung anti-viral immunity

W. D. Jackson, C. Giacomassi, S. Ward, A. Owen, T. Luis, S. Spear, K. J. Woollard, C. Johansson, J. Strid, M. Botto

This study shows that TLR7 activation at epithelial barriers triggers emergency myelopoiesis, leading to reduced lung viral load during RNA virus infection.

bioRxiv · Feb 6, 2023Immunology

Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma

Y. Xu, S. Spear, Y. Ma, M. P. Lorentzen, M. Gruet, F. McKinney, Y. Xu, C. Wickremesinghe, M. Shepherd, I. McNeish, H. C. Keun, A. Nijhuis

This study shows that combining RBM39 degraders with PARP inhibitors improves PARP inhibitor response in ovarian cancer, regardless of BRCA1/2 status.

bioRxiv · Jan 18, 2023Cancer Biology

Dual G9A and EZH2 inhibition stimulates an anti-tumour immune response in ovarian high-grade serous carcinoma

P. Spiliopoulou, S. Spear, H. Mirza, I. Garner, L. Mcgarry, F. Grundland-Freile, Z. Cheng, D. Ennis, S. McNamara, M. Natoli, S. Mason, K. Blyth, P. Adams, P. Roxburgh, M. Fuchter, , I. McNeish

This study shows that dual inhibition of G9A and EZH2 in ovarian cancer enhances anti-tumour immune responses by altering the immune microenvironment and reducing tumour growth.

bioRxiv · May 9, 2021Cancer Biology

Phylogenetic, population genetic, and morphological analyses reveal evidence for one species of Eastern Indigo Snake (Drymarchon couperi)

B. Folt, J. Bauder, S. Spear, D. Stevenson, M. Hoffman, J. Oaks, C. Jenkins, D. Steen, C. Guyer

The paper rejects the two-species hypothesis for Drymarchon couperi by showing phylogenetic, population genetic, and morphological evidence supports a single species.

bioRxiv · Oct 26, 2018 · PreprintZoology