S. Ward

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

The paper analyzes TAD boundaries across species to show evolutionary conservation and functional significance, finding ultraconserved boundaries have stronger insulation and CTCF binding.

TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung anti-viral immunity

This study shows that TLR7 activation at epithelial barriers triggers emergency myelopoiesis, leading to reduced lung viral load during RNA virus infection.

Genomic evolution of non-small cell lung cancer patient-derived xenograft models

This study examines how well PDX models capture intratumour heterogeneity in NSCLC, finding that most models originate from a single subclone but regional models can capture diversity.

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

Immunogenomic profile of colorectal cancer response to immune checkpoint blockade

This study identifies immunogenomic features predicting response to immune checkpoint blockade in colorectal cancer, showing that high clonality and immune escape mechanisms are more important than mutational burden.

Co-option of the lineage-specific LAVA retrotransposon in the gibbon genome

This study investigates the role of the lineage-specific LAVA retrotransposon in gibbon gene regulation, finding it overlaps with enhancer chromatin states and is associated with gene expression and selection.

Natural IgE promotes epithelial hyperplasia and inflammation-driven tumour growth

This study shows natural IgE promotes epithelial hyperplasia and inflammation-driven tumour growth in inflamed skin.

The Biological Evaluation of Fusidic Acid and Its Hydrogenation Derivative as Antimicrobial and Anti-inflammatory Agents

This study evaluates fusidic acid and its hydrogenation derivative for antimicrobial and anti-inflammatory effects against Gram-positive bacteria and in a mouse model.