Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes
A. S. Chawla, H. J. Watt, S. A. Schattgen, N. Skariah, I. Saha, K. Warrick, M. Ogawa, F. Lamoliatte, J. Strid, A. Copland, S. Pryde, E. Knatko, K. D. Rasmussen, K. Kikuchi, P. G. Thomas, , M. Swamy
The paper identifies a conserved mechanism, RePrESS, by which autoreactive innate-like T cells maintain tolerance through rewiring of the TCR signalosome.
bioRxiv · Sep 1, 2023 · PreprintImmunology