Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4
B. Ekundayo, P. Arullampalam, C. Gerber, A.-F. Haemmerli, S. Guichard, M. Boukenna, D. Ross-Kaschitza, M. Lochner, J.-S. Rougier, H. Stahlberg, H. Abriel, D. Ni
The paper identifies the binding site of small molecule inhibitors NBA and IBA in TRPM4 using cryo-EM and patch clamp experiments.
bioRxiv · Jan 22, 2024Biochemistry