Author

S. Guichard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:electrophysiology· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. Abriel· 4 shared J.-S. Rougier· 4 shared D. Ross-Kaschitza· 2 shared L. Gillet· 2 shared M. C. Essers· 2 shared A. Seljmani· 1 shared A.-F. Haemmerli· 1 shared A.-F. Hämmerli· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersPhysiology

H. Abriel

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Author profile →

4 papers

Recent·Most cited

Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4

B. Ekundayo, P. Arullampalam, C. Gerber, A.-F. Haemmerli, S. Guichard, M. Boukenna, D. Ross-Kaschitza, M. Lochner, J.-S. Rougier, H. Stahlberg, H. Abriel, D. Ni

The paper identifies the binding site of small molecule inhibitors NBA and IBA in TRPM4 using cryo-EM and patch clamp experiments.

bioRxiv · Jan 22, 2024Biochemistry

Role of 14-3-3 proteins in human cardiac sodium channel Nav1.5 regulation

O. Iamshanova, A.-F. Hämmerli, E. Ramaye, A. Seljmani, D. Ross-Kaschitza, N. Schärz, M. Essers, S. Guichard, J.-S. Rougier, H. Abriel

This study investigates the role of 14-3-3 proteins in regulating the human cardiac sodium channel Nav1.5 using heterologous expression in tsA201 cells and finds no significant regulatory effect.

bioRxiv · Oct 26, 2022Biophysics

A distinct pool of Nav1.5 channels at the lateral membrane of murine ventricular cardiomyocytes

J.-S. Rougier, M. C. Essers, L. Gillet, S. Guichard, S. Sonntag, D. Shmerling, H. Abriel

This study investigates the role of 1-syntrophin in regulating sodium current at the lateral membrane of cardiomyocytes and identifies a sub-pool of Nav1.5 channels independent of 1-syntrophin and the PDZ-binding motif.

bioRxiv · Mar 9, 2019Physiology

Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter

L. Gillet, S. Guichard, M. C. Essers, J.-S. Rougier, H. Abriel

This study shows that MHC-Cre mice exhibit reduced dystrophin and calcium current, unlike TNT-Cre mice, highlighting the need for Cre-only controls in experiments.

bioRxiv · Feb 1, 2019Physiology