Author

P. Arullampalam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:electrophysiology· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

H. Abriel· 4 shared J.-S. Rougier· 3 shared D. Ross-Kaschitza· 2 shared M. C. Essers· 2 shared M. Lochner· 2 shared A.-F. Haemmerli· 1 shared B. Ekundayo· 1 shared B. Preti· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersPhysiology

H. Abriel

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Author profile →

4 papers

Recent·Most cited

Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4

B. Ekundayo, P. Arullampalam, C. Gerber, A.-F. Haemmerli, S. Guichard, M. Boukenna, D. Ross-Kaschitza, M. Lochner, J.-S. Rougier, H. Stahlberg, H. Abriel, D. Ni

The paper identifies the binding site of small molecule inhibitors NBA and IBA in TRPM4 using cryo-EM and patch clamp experiments.

bioRxiv · Jan 22, 2024Biochemistry

Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice

P. Arullampalam, M. C. Essers, J. S. Rougier, H. Abriel

This study shows that TRPM4 knockdown in mice affects cardiac electrophysiology and hemodynamics differently in males and females, with effects becoming apparent in adulthood.

Physiological Reports · Aug 21, 2023Peer-reviewedPhysiology

Species-specific effects of cation channel TRPM4 small-molecule inhibitors

P. Arullampalam, B. Preti, D. Ross-Kaschitza, M. Lochner, J.-S. Rougier, H. Abriel

This study compares the effects of TRPM4 inhibitors on human and mouse TRPM4 channels, revealing species-specific responses and highlighting the need for in vivo validation.

bioRxiv · Jun 1, 2021Pharmacology & Toxicology

Deletion of Trpm4 alters the function and expression of NaV1.5 channel in murine cardiac myocytes

L. C. Ozhathil, J.-S. Rougier, P. Arullampalam, M. C. Essers, H. Abriel

This study shows that Trpm4 deletion in mice reduces NaV1.5 expression and Na+ currents in cardiac myocytes, leading to altered electrophysiological properties.

bioRxiv · Jul 6, 2020Physiology