Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo, not linked to the type I interferon response.
M. Bourdon, C. Manet, L. Conquet, C. Ramauge-Parra, E. Kornobis, E. Bonnefoy, X. Montagutelli
This study identifies an Irf3 mutation causing defective type-I interferon response in vitro in a susceptible mouse strain but shows other genetic factors are required for in vivo susceptibility to ZIKV.
bioRxiv · Mar 27, 2023 · PreprintMicrobiology