Author

D. R. Spring

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. Alcaide· 1 shared A. Asteian· 1 shared A. Cooke· 1 shared A. Garcia-Gimenez· 1 shared A. Godsinia· 1 shared A. Higueruelo· 1 shared A. J. Counsell· 1 shared A. R. Fard· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Alcaide

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents

S. R. Stockwell, D. E. Scott, G. Fischer, E. Guarino, T. P. C. Rooney, T.-S. Fang, T. Moschetti, R. Srinivasan, E. Alza, A. Asteian, C. Dagostin, A. Alcaide, M. Rocaboy, B. Blaszczyk, A. Higueruelo, , M. Hyvönen

The paper develops selective Aurora A-TPX2 inhibitors that show in vivo efficacy and synergy with paclitaxel in pancreatic cancer.

bioRxiv · Mar 22, 2023 · PreprintBiochemistry

A Recombinant Approach For Stapled Peptide Discovery YieldsInhibitors of the RAD51 Recombinase

T. Pantelejevs, P. Zuazua-Villar, O. Koczy, A. J. Counsell, S. J. Walsh, N. S. Robertson, D. R. Spring, J. A. Downs, M. Hyvonen

This paper describes a recombinant approach for stapled peptide discovery and evaluates its effectiveness as inhibitors of the RAD51 recombinase.

bioRxiv · Feb 24, 2023Biochemistry

LGR5 targeting molecules as therapeutic agents for multiple cancer types

H.-C. Chen, N. Mueller, K. Stott, E. Rivers, C. Kapeni, C. M. Sauer, F. Beke, S. Walsh, N. Ashman, L. M. O'Brien, A. R. Fard, A. Godsinia, F. Joud, O. Giger, I. Zlobec, , M. de la Roche

This study develops LGR5-targeting antibodies and therapeutics that effectively kill CRC, HCC, and pre-B ALL cancer cells while sparing normal tissues.

bioRxiv · Sep 1, 2022 · PreprintCell Biology

Formation of flavone-based wooly fibres by glandular trichomes of Dionysia tapetodes.

M. Bourdon, J. Gaynord, K. Muller, G. Evans, S. Wallis, P. Aston, D. R. Spring, R. Wightman

The paper investigates the formation of wooly fibres in Dionysia tapetodes, showing they are composed of flavone derivatives and extruded through specific cell membrane sites.

bioRxiv · Oct 6, 2020 · PreprintPlant Biology

GLP-1R is downregulated in beta cells of NOD mice and T1D patients

A. Recino, K. Barkan, A. Schmidt-Christensen, J. Nilsson, N. Holmes, D. Howie, D. Holmberg, P. Larsson, M. Flodstrom-Tullberg, L. Laraia, D. R. Spring, J. Hecksher-Sorensen, A. Cooke, G. Ladds, M. Wallberg

This study shows that GLP-1R is downregulated in beta cells of NOD mice and T1D patients, likely due to accelerated degradation, and suggests a role in autoimmune inflammation.

bioRxiv · Nov 17, 2019 · PreprintPhysiology