C. Su

J chain dictates the recognition of IgA by FcRL4

The paper determines that FcRL4 recognizes IgA via the J chain, revealing structural and functional differences in IgA receptor interactions.

Seeing halos: Spatial and consumer-resource constraints to landscape of fear patterns

The paper shows that coral halo patterns align with the landscape of fear hypothesis, influenced by coral spatial distribution and herbivore behavior.

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

CD5L associates with IgM via the J chain

This study identifies CD5L as a component of IgM pentamers, showing it binds to the J chain via a disulfide bond and reduces IgM binding to pIgR.

Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.

A Quadrivalent mRNA immunization elicits potent immune responses against vaccinia and monkeypox viral antigens - a step closer to a broad orthopoxvirus vaccine

This study develops an mRNA vaccine encoding four vaccinia antigens that induces strong immune responses against vaccinia and monkeypox viruses, suggesting broad orthopoxvirus protection.

Pan-cancer analysis reveals tumor microbiome associations with host molecular aberrations

This study identifies associations between tumor microbiomes and host molecular aberrations across 32 cancer types using multi-omics data from TCGA.

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elements

The paper identifies autoimmune disease-associated genes and regulatory elements by analyzing chromatin dynamics during CD4+ T cell activation using RNA-seq, ATAC-seq, and HiC.

Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula

The paper identifies a cell-cycle exit decision in Medicago truncatula root cortex cells that facilitates transcellular infection by rhizobia.

Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas

This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.

Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

This study identifies how Plasmodium falciparum proteins hijack human IgM to evade immune responses and cause severe malaria.

Transcellular progression of infection threads in Medicago truncatula roots is controlled by locally confined cell wall modifications

The paper investigates how rhizobia move through Medicago truncatula root cells by analyzing the role of SyPME and NPL in cell wall modifications during infection thread progression.

RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections

This study identifies RPG as a critical protein for infection thread formation and cellular polarization during rhizobial infections in Medicago truncatula.

Semaphorin3F reduces vascular endothelial and smooth muscle cell PI3K activation and decreases neointimal plaque formation

This study shows that Semaphorin3F reduces PI3K activation in vascular endothelial and smooth muscle cells, leading to decreased neointimal plaque formation and increased plaque stability.

Remorin proteins serve as membrane topology scaffolds in plants

The paper shows remorin proteins stabilize membrane tubules and curvature during symbiotic infections in plants.

Aspirin synergizes with regorafenib to reduce growth of colorectal cancer

This study shows that aspirin and regorafenib together reduce colorectal cancer growth in preclinical models by inhibiting the PI3K-Akt-mTOR pathway and activating AMPK.

Possible Cross Reactivity of Feline and White-tailed Deer Antibodies Against the SARS-CoV-2 Receptor Binding Domain

The paper reports cross-reactive antibodies against SARS-CoV-2 RBD in pre-pandemic feline and post-pandemic white-tailed deer sera, suggesting potential exposure to SARS-like coronaviruses.

Reactivation of Epstein Barr Virus from Latency Involves Increased RNA Polymerase Activity at CTCF Binding Sites On The Viral Genome

This paper maps RNA polymerase activity during EBV latency and reactivation, finding that CTCF binding sites are key for early bidirectional transcription during reactivation.

Multiple levels of triggered factors and positive effect of cell-to-cell bottleneck in mutation repair of RNA viruses

This study identifies multiple triggering factors for mutation repair in RNA viruses and shows that cell-to-cell movement enhances mutation repair, opposing the Muller ratchet effect.

Cryo-EM study on the homo-oligomeric ring formation of yeast TRiC/CCT subunits reveals TRiC ring assembly mechanism

This study uses cryo-EM to reveal the mechanism of TRiC/CCT ring assembly in yeast, showing subunit-specific roles and ATP-driven assembly dynamics.

Integrative genomics identifies lncRNA regulatory networks across 1,044 pediatric leukemias and extra-cranial solid tumors

The paper identifies lncRNA regulatory networks in pediatric cancers using integrated genomics data from 1,044 samples, revealing their roles in proliferation, metabolism, and DNA damage.

APC Mutation marks an aggressive subtype of BRAF mutant colorectal cancers

This study identifies APC mutations as a marker of aggressive BRAF mutant colorectal cancers, associated with poor prognosis and enhanced tumor growth in mouse models.

The Medicago truncatula DREPP protein triggers microtubule fragmentation in membrane nanodomains during symbiotic infections

This study identifies the DREPP protein in Medicago truncatula and shows it regulates microtubule reorganization during rhizobial infection by localizing to membrane nanodomains.

ELIMAKI locus is required for mechanosensing and proprioception in birch trees

The study identifies a mutant birch tree (Elimaki) with impaired proprioception and radial growth, linking mechanical stress response to cell wall properties and transcriptomic changes.