L. Conquet

Multi-target mode of action of Sulfodyne(R), a stabilized Sulforaphane, against pathogenic effects of SARS-CoV-2 infection

This paper shows that Sulfodyne(R), a stabilized Sulforaphane, reduces SARS-CoV-2-induced inflammation and disease severity in cell lines and animal models through mechanisms independent of NRF2 activation.

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo, not linked to the type I interferon response.

This study identifies an Irf3 mutation causing defective type-I interferon response in vitro in a susceptible mouse strain but shows other genetic factors are required for in vivo susceptibility to ZIKV.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

A mRNA vaccine encoding for a RBD 60-mer nanoparticle elicits neutralizing antibodies and protective immunity against the SARS-CoV-2 delta variant in transgenic K18-hACE2 mice

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice.

This study develops a mouse-adapted SARS-CoV-2 strain that replicates efficiently in standard mice and causes mild to moderate lung disease.

Variants with the N501Y mutation extend SARS-CoV-2 host range to mice, with contact transmission

The paper shows that SARS-CoV-2 variants with the N501Y mutation can infect and transmit to mice, suggesting potential for rodent reservoirs.

A measles-vectored COVID-19 vaccine induces long-term immunity and protection from SARS-CoV-2 challenge in mice