M. Boxem

SUMO-mediated regulation of a H3K4me3 reader controls germline development in C. elegans

This study identifies ULP-2/SET-26 axis regulation of germline development in C. elegans through SUMO-mediated control of H3K4me3 reader activity.

Intermediate filament network perturbation in the C. elegans intestine causes systemic toxicity

The paper shows that perturbing intermediate filament networks in C. elegans intestine causes systemic toxicity, and identifies IFB-2 as a suppressor of these effects.

ERM-1 phosphorylation and NRFL-1 redundantly control lumen formation in the C. elegans intestine

This study shows that ERM-1 and NRFL-1 work together to control intestinal lumen formation in C. elegans, with NRFL-1 compensating for ERM-1 phosphorylation defects.

Epidermal PAR-6 and PKC-3 are essential for postembryonic development of Caenorhabditis elegans and control non-centrosomal microtubule organization

This study shows that PAR-6 and PKC-3 are essential for postembryonic development in C. elegans and regulate non-centrosomal microtubule organization via NOCA-1/Ninein localization.

In vivo control of the ezrin/radixin/moesin protein ERM-1 in C. elegans

This study investigates the role of ERM-1 regulation via PIP2-binding and phosphorylation in C. elegans tissue morphogenesis and lumen formation.

Host targets of effectors of the lettuce downy mildew Bremia lactucae from cDNA-based yeast two-hybrid screening

The paper identifies 61 protein-protein interactions between Bremia lactucae effectors and lettuce proteins using yeast-two-hybrid screening, with four effector-target pairs showing nuclear relocalization.

Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin

This study investigates cisplatin sensitivity in C. elegans, identifying factors like DAF-16/FOXO, SKN-1/Nrf2, and the intrinsic apoptotic pathway, and discovers a resistance mechanism involving trxr-1 and selenocysteine.