Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells
N. Kirchhammer, M. P. Trefny, M. Natoli, D. Bruecher, S. N. Smith, F. Werner, V. Koch, D. Schreiner, E. Bartoszek, M. Buchi, M. Schmid, D. Breu, K. P. Hartmann, P. Zaytseva, D. S. Thommen, , A. Zippelius
The paper shows that CCL5-producing tissue-resident NK cells are critical for IL-12-mediated anti-tumor immunity and that CCL5 delivery can overcome resistance in tumors with low trNK cell infiltration.
bioRxiv · May 27, 2021 · PreprintImmunology