A. Plueckthun

Targeting HIV-1 with CRISPR/Cas9 delivered by retargeted adenoviruses effectively suppresses viral replication

This study combines CRISPR/Cas9 with retargeted adenoviruses to suppress HIV-1 replication in primary CD4+ T cells.

Side-Chain Dynamics of the α1B-Adrenergic Receptor determined by NMR via Methyl Relaxation

This study uses NMR methyl relaxation to analyze side-chain dynamics of the α1B-adrenergic receptor, revealing differences in flexibility between orthosteric and allosteric ligand-bound states.

Designed Ankyrin Repeat Proteins for detecting prostate-specific antigen expression in vivo

This paper develops PSA-specific DARPins for in vivo imaging to monitor drug resistance in prostate cancer.

FAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment

This study develops a FAP-targeted adenovirus for delivering therapeutics to cancer-associated fibroblasts, showing reduced tumor growth in vivo.

Nuclear myosin VI maintains replication fork stability

This study shows that nuclear myosin VI stabilizes stalled or reversed replication forks by interacting with WRNIP1 to prevent DNA2-mediated degradation during replication stress.

Biofunctional nanodot arrays in living cells uncover synergistic co-condensation of Wnt signalodroplets

The paper develops biofunctional nanodot arrays to study Wnt signalodroplets in live cells, revealing synergistic co-condensation through liquid-liquid phase separation.

Structural basis for the activation and ligand recognition of the human oxytocin receptor

This study determines the cryo-EM structure of the oxytocin receptor bound to oxytocin, revealing its activation mechanism and ligand recognition.

Structural basis of adenylyl cyclase 9 activation

The paper presents cryo-EM structures of AC9 in different states to reveal activator-induced conformational changes essential for its activation.

Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells

The paper shows that CCL5-producing tissue-resident NK cells are critical for IL-12-mediated anti-tumor immunity and that CCL5 delivery can overcome resistance in tumors with low trNK cell infiltration.

Crystal structure of the human oxytocin receptor

The paper reports the crystal structure of the human oxytocin receptor complexed with retosiban, revealing insights into antagonist interactions and a Mg2+ coordination site.

DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations

This paper generates DARPins targeting mTFP1 and uses them to delocalize Rab proteins in cultured cells, demonstrating potential for direct protein manipulation in vivo.