Cancer BiologybioRxiv
High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms
R. Thokala, Z. A. Binder, Y. Yin…·D. M. O'Rourke
This paper develops a CAR T cell with broad EGFR specificity to target multiple tumor clones and reduce antigen loss escape in glioblastoma.