Author

M. Cassandras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

C. Wang· 3 shared T. PENG· 3 shared A. Molofsky· 2 shared M. Matthay· 2 shared P. Matatia· 2 shared P. Wolters· 2 shared A. Brumwell· 1 shared C. Le Saux· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

C. Wang

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3 papers

Recent·Most cited

Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

N. Reyes de Mochel, K. N. Cheong, M. Cassandras, C. Wang, M. Krasilnikov, P. Matatia, A. Molofsky, J. Campisi, T. PENG

The paper identifies p16INK4a+ mesenchymal cells in the lung basement membrane as reparative sentinels that transition to a senescence-associated secretory phenotype to support epithelial repair.

bioRxiv · Jun 10, 2020 · PreprintCell Biology

Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair

J. J. Kathiriya, C. Wang, A. Brumwell, M. Cassandras, C. Le Saux, P. Wolters, M. Matthay, H. A. Chapman, T. Peng

This study shows human alveolar type 2 cells can transdifferentiate into KRT5+ basal cells in 3D organoids, a process linked to IPF pathology and not observed in murine cells.

bioRxiv · Jun 6, 2020 · PreprintCell Biology

Gli1+ mesenchymal stromal cells modulate epithelial metaplasia in lung fibrosis

M. Cassandras, C. Wang, J. Kathiriya, T. Tsukui, P. Matatia, M. Matthay, P. Wolters, A. Molofsky, D. Sheppard, H. Chapman, T. Peng

This study shows Gli1+ mesenchymal stromal cells drive metaplastic differentiation of airway progenitors into KRT5+ basal cells in fibrosis by modulating BMP activation through hedgehog signaling.

bioRxiv · Nov 14, 2019Cell Biology