T. Tsukui

Dynamic fibroblast-immune interactions shape wound healing after brain injury

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification

This study identifies impaired myofibroblast proliferation as a central feature of alveolar simplification in BPD using single-cell RNA sequencing and pharmacologic approaches.

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

Tracing the origin of pathologic pulmonary fibroblasts

The paper identifies alveolar fibroblasts as the main source of fibroblast subsets involved in lung fibrosis and shows their lineage progression using mouse models and human scRNA-seq data.

Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

This study shows that blocking integrin αvβ8 on T cells enhances anti-tumor immunity in multiple syngeneic models and is effective even when tumor cells do not express the integrin.

Gli1+ mesenchymal stromal cells modulate epithelial metaplasia in lung fibrosis

This study shows Gli1+ mesenchymal stromal cells drive metaplastic differentiation of airway progenitors into KRT5+ basal cells in fibrosis by modulating BMP activation through hedgehog signaling.

Broadly Conserved Roles of TMEM-131 Family Proteins in Intracellular Collagen Assembly and Secretory Cargo Trafficking

This study identifies TMEM-131 family proteins as conserved regulators of collagen assembly and secretion across species, showing their role in ER stress and collagen production.