Cell BiologybioRxiv
Gli1+ mesenchymal stromal cells modulate epithelial metaplasia in lung fibrosis
M. Cassandras, C. Wang, J. Kathiriya…·T. Peng
This study shows Gli1+ mesenchymal stromal cells drive metaplastic differentiation of airway progenitors into KRT5+ basal cells in fibrosis by modulating BMP activation through hedgehog signaling.
DOI 10.1038/s41556-020-00591-9