M. Cetin

Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer

This study identifies LINC00152 as a driver of tamoxifen resistance in ER+ breast cancer by inhibiting ferroptosis, and shows that targeting LINC00152 restores sensitivity to tamoxifen.

Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer

This study shows that T-DM1 induces immunogenic cell death (ICD) in HER2-positive breast cancer, which is lost in resistance, and that targeting TACC3 restores ICD and enhances T-DM1 response.

T-FINDER: A highly sensitive, pan-HLA platform for functional T cell receptor and ligand discovery

T-FINDER identifies T cell epitopes and their cognate receptors by analyzing HLA-presented peptides, demonstrating its utility in multiple diseases.

Doxorubicin induces prolonged DNA damage signal in cells overexpressing DEK isoform-2.

This study shows that DEK isoform-2 induces prolonged DNA damage signals and is functionally distinct from DEK isoform-1 in response to doxorubicin.

Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification

This study identifies TACC3 as a therapeutic target in breast cancers with centrosome amplification, showing its inhibition leads to apoptosis and growth suppression in organoids and xenografts.

New Insights into Molecular Basis Identification of Three Novel Strains of the Bacillus Subtilis Group Produce Cry Proteins Isolated from Soil Samples in Adana, Turkey

The paper identifies three novel Bacillus subtilis group strains producing Cry proteins from soil samples in Adana, Turkey, using phylogenetic and SNP analysis.