M. E. DeSantis

HIV-1 binds dynein directly to hijack microtubule transport machinery

This study shows HIV-1 directly binds dynein to hijack microtubule transport for motility, bypassing traditional cargo adaptors.

Ndel1 modulates dynein activation in two distinct ways

This study identifies two distinct mechanisms by which Ndel1 inhibits dynein activation in vitro, contrasting with its role in promoting dynein activity in cells.

Structures of human cytoplasmic dynein in complex with the lissencephaly 1 protein, LIS1

The paper reports cryo-EM structures of human dynein-LIS1 complexes, revealing differences from yeast and mapping disease mutations.

The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor

The paper identifies KASH5 as a dynein activating adaptor essential for meiotic chromosomal movements, showing it binds dynein and enables processive motility.

Lis1 promotes the formation of maximally activated cytoplasmic dynein-1 complexes

This paper identifies Lis1's role in forming maximally activated dynein complexes by binding to dynein's motor domain, enhancing microtubule binding and velocity.

Lis1 has two opposing modes of regulating cytoplasmic dynein

This study reveals that Lis1 regulates cytoplasmic dynein through two opposing modes of microtubule-binding affinity, dependent on Lis1 stoichiometry and dynein's nucleotide state.

The Human Cytoplasmic Dynein Interactome Reveals Novel Activators Of Motility

The paper identifies ninein and ninein-like as new dynein activators using BioID, revealing their role in cargo binding and motility.