T. W. Giessen

The paper shows that a single point mutation in a virus-like capsid can drive the formation of tetrahedral structures instead of the typical icosahedral symmetry.

The paper reports the structural characterization of the cyclodipeptide oxidase AlbAB from Streptomyces noursei, revealing it as a filamentous enzyme essential for antibiotic biosynthesis.

This study determines the structural basis for encapsulating dye-decolorizing peroxidases in a protein nanocompartment using cryo-EM and mutagenesis.

This study shows HIV-1 directly binds dynein to hijack microtubule transport for motility, bypassing traditional cargo adaptors.

The paper reports the cryo-EM structure of a highly cargo-loaded encapsulin shell and identifies structural distortions caused by high cargo loading.

The paper identifies desulfurase encapsulins as a novel sulfur storage compartment in bacteria, showing they sequester elemental sulfur and enhance desulfurase activity.

This study characterizes AaEnc, an acid-stable encapsulin nanocage from Acidipropionibacterium acidipropionici, revealing its pH-dependent dynamic pore and extreme acid tolerance.

This paper develops a cell-free system to study LINC complex assembly by reconstituting membrane proteins in lipid bilayers and shows its utility in investigating chemical and molecular factors affecting protein interactions.

The paper identifies and analyzes over 6,000 encapsulin-like systems across bacterial and archaeal phyla, revealing novel families and operons, and proposes evolutionary links to HK97-type bacteriophages.