Author

J. Nandakumar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Organism:bacteria (other)· 1 Research Focus:clustering· 1

Frequent Co-Authors

R. Agrawal· 2 shared A. Crayton· 1 shared A. Diehl· 1 shared A. Friedman· 1 shared A. Moroz· 1 shared A. Mychalowych· 1 shared A. N. Shami· 1 shared A. Vanderbeck· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

R. Agrawal

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5 papers

Recent·Most cited

Structural and biochemical characterization of the mitomycin C repair exonuclease MrfB

K. A. Manthei, L. M. Munson, J. Nandakumar, L. A. Simmons

The paper characterizes MrfB, a DEDDh exonuclease involved in repairing mitomycin C-induced DNA damage in Bacillus subtilis, revealing its structural and biochemical properties.

bioRxiv · Feb 15, 2024Biochemistry

The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor

R. Agrawal, J. P. Gillies, J. L. Zang, J. Zhang, S. R. Garrott, H. Shibuya, J. Nandakumar, M. E. DeSantis

The paper identifies KASH5 as a dynein activating adaptor essential for meiotic chromosomal movements, showing it binds dynein and enables processive motility.

bioRxiv · Mar 11, 2022Cell Biology

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

J. V. Graniel, K. Bisht, A. Friedman, J. White, E. Perkey, A. Vanderbeck, A. Moroz, L. J. Carrington, J. D. Brandstadter, F. Allen, A. N. Shami, P. Thomas, A. Crayton, M. Manzor, A. Mychalowych, , J. Nandakumar

This study examines the impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline, finding progressive telomere erosion and infertility without bone marrow failure.

Life Science Alliance · Oct 13, 2021Peer-reviewedCell Biology

Single residue substitution in protamine 1 disrupts sperm genome packaging and embryonic development in mice

L. Moritz, S. Schon, M. Rabbani, Y. Sheng, D. Pendlebury, R. Agrawal, C. Sultan, K. Jorgensen, X. Zheng, A. Diehl, K. Ragunathan, Y.-C. Hu, J. Nandakumar, J. Li, K. Orwig, , S. Hammoud

This study shows that a single amino acid substitution in mouse protamine 1 disrupts DNA packaging and causes infertility by altering protein function and developmental outcomes.

bioRxiv · Sep 16, 2021 · PreprintBiochemistry

Two separation-of-function isoforms of human TPP1 and a novel intragenic noncoding RNA dictate telomerase regulation in somatic and germ cells.

S. Grill, K. K. Bisht, V. M. Tesmer, C. J. Sifuentes, J. Nandakumar

The paper identifies two TPP1 isoforms with distinct telomerase regulatory functions and shows an intragenic noncoding RNA controls their expression in somatic and germ cells.

bioRxiv · May 3, 2019Biochemistry