PhysiologybioRxivPreprint
BACE1, but not BACE2, function is critical for metabolic disorders induced by high-fat diets in C57BL/6N mice
T. W. Rosahl, L. A. Hyde, P. T. Reilly…·M. E. Kennedy
This study shows that BACE1, but not BACE2, knockout improves metabolic outcomes in mice on a high-fat diet, suggesting BACE1 inhibition may enhance metabolic homeostasis.
DOI 10.1101/2021.12.20.473491