NLRP3 Cys126 palmitoylation by ZDHHC7 Promotes Inflammasome Activation
T. Yu, D. Hou, J. Zhao, X. Lu, W. K. Greentree, Q. Zhao, D.-G. Conde, M. E. Linder, H. Lin
This study identifies ZDHHC7-mediated palmitoylation of NLRP3 at Cys126 as critical for inflammasome activation, with implications for therapeutic targeting of inflammatory diseases.
bioRxiv · Nov 7, 2023Immunology