ImmunologybioRxivPreprint
Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction
M. E. Selli, J. H. Landmann, M. Terekhova…·N. Singh
This study identifies that chronic activation of 41BB-based CARs leads to a novel T cell dysfunction state, distinct from exhaustion, which can be mitigated by disrupting FOXO3.
DOI 10.1101/2023.01.26.525725