Author

M. Eldeeb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

J.-F. Trempe· 2 shared A. Bayne· 1 shared A. Fallahi· 1 shared A. Soumbasis· 1 shared C. Zorca· 1 shared E. A. Fon· 1 shared E. Fon· 1 shared E. McDougall· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

J.-F. Trempe

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Author profile →

2 papers

Recent·Most cited

TOM20 Gates PINK1 Activity And Mediates Its Tethering Of The TOM And TIM23 Translocases Upon Mitochondrial Stress

M. Eldeeb, A. Bayne, A. Fallahi, T. Goiran, E. McDougall, A. Soumbasis, C. Zorca, J.-J. Tabah, R. Thomas, N. Karpilovsky, M. Mathur, T. Durcan, J.-F. Trempe, E. Fon

This study shows PINK1 forms a supercomplex with TOM and TIM23 during mitochondrial stress and is required for tethering TOM to TIM23, which is essential for mitophagy.

bioRxiv · Aug 7, 2023Biochemistry

Structure of PINK1 reveals autophosphorylation dimer and provides insights into binding to the TOM complex

S. Rasool, S. Veyron, N. Soya, M. Eldeeb, G. Lukacs, E. A. Fon, J.-F. Trempe

The paper reports crystal structures of insect PINK1, revealing a dimeric autophosphorylation complex and insights into its binding to the TOM complex.

bioRxiv · Aug 5, 2021Biochemistry